Actions of bretylium tosylate at the neuromuscular junction
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چکیده
منابع مشابه
The actions of tubocurarine at the frog neuromuscular junction.
1. The action of tubocurarine on voltage-clamped frog muscle end-plates has been re-examined by means (a) equilibrium dose-ratio measurements, (b) current fluctuation measurements and (c) voltage-jump relaxation measurements. 2. The equilibrium measurements can be interpreted as implying that tubocurarine has (a) a competitive blocking action, with a dissociation constant of 0.34 microM, which ...
متن کاملPrevention of chronic canine ventricular tachyarrhythmias with bretylium tosylate.
The ability of chronic bretylium tosylate treatment to prevent the induction of ventricular tachycardia was assessed in the conscious dog subjected to serial programmed ventricular stimulation on days 3-6 after acute myocardial infarction. In 34 untreated control dogs, programmed ventricular stimulation produced nonsustained ventricular tachycardia in 11 dogs (32%), sustained ventricular tachyc...
متن کاملBretylium tosylate in prevention of cardiac dysrhythmias after myocardial infarction.
The prophylactic value of parenterally administered bretylium tosylate against the onset of dysrhythmias after acute myocardial infarction has been assessed by a controlled trial in 101 male patients. Bretylium significantly reduced the incidence of supraventricular dysrhythmias but was without significant effect on the incidence of ventricular dysrhythmias. The only serious side-effect of the ...
متن کاملEffect of bretylium tosylate (Darenthin) on pulmonary circulation.
BRETYLIUM tosylate (Darenthin, Burroughs Wellcome), is one of the series of benzyl quaternary ammonium compounds which blocks selectively the peripheral sympathetic nervous system without antagonizing the effects of epinephrine. This block occurs without depression of the parasympathetic or central nervous system.' Its effect on the pulmonary circulation has not hitherto been investigated. ,_ ....
متن کاملEffectiveness of bretylium tosylate against refractory ventricular arrhythmias.
Thirty patients with ventricular tachyarrhythmias, which had not responded to intensive therapy with up to five antiarrhythmic drugs, were treated with bretylium tosylate. All patients had recurrenit ventricular tachycardia, and 12 had repeated episodes of ventricular fibrillation. In 17 patients the arrhythmias followed acute myocardial infarction. Bretylium was administered intramuscularly or...
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ژورنال
عنوان ژورنال: British Journal of Pharmacology
سال: 1971
ISSN: 0007-1188
DOI: 10.1111/j.1476-5381.1971.tb07069.x